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19 Although the mechanisms underlying endothelial dysfunction are multifactorial, a growing body of evidence suggests that increased ROS production contributes considerably to this phenomenon in several ways

At the cellular level, 3-HK promotes apoptosis by increasing mitochondrial membrane permeability, facilitating cytochrome C release and caspase-dependent cell death accompanied by oxidative damage [139, 154]

[1] Cellular Energy Production - Glutathione protects mitochondria (the cell's power plants) from oxidative damage, potentially supporting more efficient energy production during exercise

For details, see the B6 section of the B Vitamin Supplements Review