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Starting with lower doses and gradually titrating upwards, as recommended in prescribing guidelines, can help minimise gastrointestinal symptoms

The unabsorbed fat is then excreted in the stool, which can lead to side effects such as oily stools, flatulence, and fecal urgency, especially when consuming high-fat meals

This substitution makes the peptide resistant to dipeptidyl-peptidase-4 (DPP-4), whereas the C18 fatty di-acid side chain attached to Lys26 ensures high-affinity, reversible albumin binding

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It is not approved by the FDA for clinical use