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The pathophysiology of neuropathic pain varies and includes ectopic activity in damaged nerves or in adjacent nerves, dorsal root ganglion (DRG) or central pathways, and peripheral and central sensitisation involving numerous molecular mechanisms

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This differs from the majority of heparin-binding proteins, which bind through basic amino acid sequences containing primarily lysine and arginine (Hileman et al., 1998), but is common for histidine-proline-rich glycoprotein (HPRG) (Liu et al., 2018)

doi: 10.1038/s41598-017-16488-x 199 BianchiMDOriaVBraghiniMRPetriniSMancoM