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Journal of Cutaneous and Aesthetic Surgery

The gradual progression serves pharmacodynamic purposes beyond simple tolerability, allowing metabolic adaptations to develop fully

So it's like an ongoing process

Clinical improvement was also observed in oxidative stress markers, with improvements in methionine levels (p=0.05), homocysteine levels (SAH, p=0.007) and the ratio of S-adenosylmethionine (SAMe) to SAH (p=0.007), indicating improvement with methylation at the cellular level and a decrease in oxidative stress in the body 2