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PMID: 27778306 Richie JP Jr, et al

For the most stable conformation, observed at 85 and 86 ns, the residues ASP3 and ASP7 require the inclusion of calcium ions, along with ASP9 and LMG12, which may further stabilize the transition state to the structural conformation with the highest affinity for the membrane model

It should be noted that there were slightly more male participants enrolled in the study, participants were predominantly white (reflective of the demographics of the study location) and a high proportion of participants had CV-related medical history

The thing is, its not always about fiber amount , sometimes its about timing and type