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The gasdermin-N domains of GSDMD can bind the membrane lipids, phosphoinositides and cardiolipin, and exhibit membrane-disrupting cytotoxicity in mammalian cells, and thus triggering pyroptosis ( 2 on NLRP3 inflammasome activation and the subsequent pyroptosis in the liver of mice fed with a MCD diet, we examined NLRP3, ASC, Caspase-1 and GSDMD protein levels in the liver
Notably, microbiota reintroduction into GF mice partially restores immune cell populations and function, depending on bacterial strain composition and the timing of colonization [34, 35]
Potentiates glucose-dependent insulin secretion through the GIP and GLP-1 incretin arms in pancreatic beta-cell assays
