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These genetic insights may help provide context for why some individuals experience more pronounced thermoregulatory shifts during GLP-1 therapy

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95% CI, 0.54-0.94), all-cause mortality (HR = 0.59

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The bulkier proline occupies more of the S1 pocket than does alanine, which explains the higher affinity for peptides with proline versus alanine at the second position

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