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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists in persons with obesity and knee osteoarthritis in this population has not been well-established. To test the impact of a GLP-1 receptor weight loss medication on knee OA outcomes, Bliddal and colleagues conducted a double-blind, randomized, placebo-controlled trial at 61 sites across 11 countries

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The GIP component likely improves insulin sensitivity and fat oxidation through pathways distinct from GLP-1, which helps explain the stronger results

Peptide aggregation is a particular concern, as aggregated proteins may be ineffective and could potentially trigger an immune response

Because cysteine is relatively scarce in the standard diet, its availability often acts as the bottleneck for glutathione production