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This hypothalamic response subsequently promotes the development of brain leptin resistance and then- obesity
exclusively for research purposes and is not approved for human consumption
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Then in May 2025, the first direct head-to-head trial SURMOUNT-5 was published in the New England Journal of Medicine , putting the two medications head-to-head in the same patients, at the same time, under the same conditions
PMC 4761105
The surgery was performed on the right hind limb and the left limb served as a control
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