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To combat side effects, its typical to begin at a low dose and incrementally increase

This mechanistic diversity suggests that GLP-1RAs could be repurposed to target complex, multifactorial disorders like schizophrenia, bipolar disorder, and bulimia nervosa, where current treatment options are limited or suboptimal

The researchers estimated that this translated to seven fewer new substance use disorder diagnoses per 1,000 GLP-1 users

Serious adverse events and complications of these medications may include Gastroparesis (paralysis of the stomach), NAION vision loss, Ileus, Pancreatitis, Wernickes Encephalopathy, Bowel obstruction (blocked intestine), Malnutrition requiring hospitalization, and Pulmonary aspiration while under anesthesia or during surgery

A more useful definition is a stable weekly-average weight for approximately three to four weeks despite consistent medication use and no obvious change in food intake, activity, or fluid balance