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110 However, in one large placebo-controlled trial in 2,370 men with infertility, treatment with 30 mg of elemental zinc plus 5 mg (8,500 mcg DFE) folic acid daily for six months increased DNA fragmentation and did not lead to improvements in sperm parameters or pregnancy rate

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Different factors such as age and diet may significantly decrease its production over time

The GIP receptor activation in adipose tissue may provide additional benefits for fat mobilization and metabolism, though the clinical significance of these mechanistic differences requires further study