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Consequence 2: Nicotinamide salvage interference

Serious side effects are rare at recommended doses, but users should monitor for any unusual symptoms and consult healthcare providers if concerns arise

Other nutrient deficiencies impede cofactors

Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction