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In the STEP 1 trial, adults with obesity who received semaglutide 2.4 mg weekly achieved a mean weight loss of 14.9% of initial body weight over 68 weeks, compared to 2.4% with placebo
This is the question that cuts through the noise fast, so heres the actual answer from the most referenced research on this
Maintain adequate hydration , especially if you experience gastrointestinal symptoms, to prevent dehydration and potential kidney problems
M., et al., for the STEP 1 Study Group
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