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Landmark trials like SUSTAIN-6 and LEADER found that semaglutide caused symptomatic hypoglycemia in fewer than 5% of participants using the medication alone, but rates exceeded 20% in subgroups taking insulin concurrently
Compared with active drugs, oral semaglutide was superior to empagliflozin in reducing total cholesterol and LDL [36] and was superior to sitagliptin in reducing total cholesterol, LDL, and TAGs [37, 41], but there was no significant difference when compared with another GLP-1 analogue (liraglutide) [38]
Effective weight management with GLP can reduce the risk of developing a myriad of obesity-related conditions
Preliminary evidence suggests potential benefits, though larger trials are needed before any clinical recommendations can be made
Th1 cells fight intracellular pathogens and drive cellular immunity
