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HGF protects endothelial cells from hypoxic death by the AKT pathway and p38 MAPK , as well as through the enhancement of Bcl-2 expression (Yamamoto et al., 2001

Given BPC-157's angiogenic properties (VEGF upregulation), theoretical concern exists about promoting vascular growth in hepatocellular carcinoma, though no case reports have documented this outcome [1]

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