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Incorporation of a trifluoromethyl group at the 6-position of the tetrahydropyran ring in omarigliptin (with a (2R, 3S, 5R, 6S) configuration) was found not only to enhance the pharmacokinetic profile in mice but also to maintain robust DPP-4 inhibitory activity
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Oxidative Stress: As glutathione decreases, oxidative stress increases dramatically
The limitations of the study, as acknowledged by the authors, include the lack of individual patient data and the relatively low percentage of participants with a history of stroke
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