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GLP-1 drugs target the GLP-1 trans-membrane receptor, which is one of a large family of G protein-coupled receptor (GPCR) proteins that straddle cell membranes and transduce chemical signals from outside the cell to its interior
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This makes them a versatile tool in functional medicine for supporting overall gut function
(1988) characterized IGFBP binding determinants in the IGF-1 molecule, providing the structural basis for the R3 substitution that became the foundation of the LR3 design (PMID 3356790)
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