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SodiumGlucose Cotransporter Inhibitors Function of SodiumGlucose Cotransporters in the Human Body Sodiumglucose cotransporter-2 (SGLT2) is a high-capacity, low-affinity transporter located solely in the luminal membrane of the S1 and S2 segments of the proximal convoluted tubule of nephrons, and they are responsible for about 90% of renal glucose reabsorption

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Unlikely to occur in humans unless severe overdose occurs.UDPGA transport from cytosol to ER can be rate limiting in vitro.Some compounds can deplete UDPGA by other mechanisms, eg

It regulates caloric intake and improves body composition by reducing fat while preserving lean mass