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In a systematic review article that included 40 clinical trials, tirzepatide at 15 mg ranked first in terms of HbA1c reduction rate, compared to other GLP-1RA-based strategies, and even those including insulin

In rodents, GLP-1 has been shown to increase the biosynthesis of glucose transporter 2 (GLUT-2) and glucokinase [29]

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Effect of carnitine supplementation on mitochondrial enzymes in liver and skeletal muscle of rat after dietary lipid manipulation and physical activity

This delayed gastric emptying is the main culprit behind the constipation side effect