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The primary mechanism of action involves: Stimulating insulin secretion in a glucose-dependent manner Suppressing glucagon release when blood glucose is elevated Slowing gastric emptying to promote satiety Acting on central nervous system pathways that regulate appetite For type 2 diabetes, these medications typically reduce hemoglobin A1c by 1.01.5%
A recent 2025 report in JAMA ophthalmology, has also found that patients with longer durations of exposure to GLP-1 agonists were associated with a higher risk of developing neovascular age-related macular degeneration
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These types of foods can lead to persistent hunger
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