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Moreover, inflammation dysregulates neurotrophins such as BDNF and NGF, which are essential for neuronal growth and plasticity via TrkA/B/C and p75^NTR^ signaling pathways (Numakawa and Kajihara 2023
Long-standing GERD with significant esophageal damage may require longer treatment periods and show slower response compared to milder, more recent-onset reflux
These are not minor protocol deviations
At the clinic, there were 228 prescriptions written for GLP-1s in 2022
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