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A prospective proof-of-concept study by Nicolau et al 19 found that liraglutide treatment for three months resulted in a decrease in BMI (from 39.3 to 35.6 kg/m 2 ), waist circumference (from 121.3 to 110.6 cm), mean Hurley stage (from 2.6 to 1.1), DLQI (from 12.3 to 9.7), Beck Depression Inventory (BDI) (from 22 to 16.7), and visual analog scale (VAS) for pain (from 5.6 to 3.2), as well as a decrease in inflammatory markers such as CRP (from 4.5 to 3 mg/dL), homocysteine (from 16.2 to 13.3 mol/L), plasma morning cortisol (from 15.9 to 12.6 g/dL), and insulin (from 18.9 to 15.7 U/mL)

People with obesity or type 2 diabetes may also show small differences in exposure compared to leaner participants

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contamination or mis-labeled content is a real-world risk that no dosing table can protect against

The semaglutide component could cause serious adverse effects if ingested by children