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As we age, they can be more likely to suffer from adult-onset growth hormone deficiency (AGHD), characterized by a relative increase in fat mass, and a decrease in muscle mass
Supplementation helps bridge the gap, but the method of supplementation matters
What the Research Shows Recent research on semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) has revealed concerning trends about body composition changes: A 2023 analysis of STEP trial data found that approximately 39% of weight lost on semaglutide was lean body mass 1 Research on tirzepatide showed similar patterns, with 30-40% of total weight loss coming from lean tissue 2 Comparative studies indicate GLP-1 users may lose more muscle than people losing weight through diet and exercise alone 3 For context: if you lose 50 pounds on a GLP-1 medication, 15-20 pounds might be muscle mass
Acknowledgments The authors express their gratitude to the editorial office and the reviewers for their thorough and patient review
Half of the weight she lost has already come back
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