Transient erythema, pruritus, or stinging may develop at the application site, typically resolving with continued use or brief treatment interruption
Eisenbraun J, Scheer R, Krz M, Schad F, Huber R
These symptoms progress gradually, but if untreated, could be permanent
Five-week-old igf-1 global knockouts failed to display the anabolic responses to intermittent PTH observed in wild-type animals such as increased serum osteocalcin and alkaline phosphatase levels, increased alkaline phosphatase activity in femoral bone extracts, higher BMD and increased bone formation

In the above technical solution, in step 5, the freeze-drying comprises the following steps, preparing liquid and filling at 20-30 , putting a sample into a freeze dryer, quickly reducing the temperature of a plate layer to-40 , preserving heat for 1h, when the temperature of a partition plate is-10 +/-2 , preserving heat for 1h, quickly reducing the temperature of the plate layer to-40 within 1h, preserving heat for 3h, transferring to a cold trap at-50 , vacuumizing to below 10Pa, firstly preserving the temperature of the plate layer at-5 for 3h, then heating the plate layer to 10 within 3h, when a product is at 0 , starting to increase the temperature of the plate layer to 40 , and when the product is increased to 30 , preserving heat for 5 h