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p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]
Tempered expectations are common
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All these observations are challenged by longer term in vivo studies
Sokolov Frontiers in Medicine .2026;[Epub] CrossRef Panax notoginseng Saponins Ameliorate HighFat DietInduced Liver Injury via Mechanisms Involving TLR4Mediated Signaling and Lipid Metabolism Rong Li, Junyu Ma, Mengyao Li, Bangzhao Zeng, Xuexun Li, Xiaoyan Bi, Xin Zhao, Qin Gao, Yanling Yao, Yang Jiang, Chunmei Zhang, Fuli Ya Food Science & Nutrition .2026;[Epub] CrossRef MicroRNA-146a Protects against Hepatocellular Carcinoma through Suppression of CCL5 Morgan C
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