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If you take certain medications: Talk with your clinician before taking berberine if you take medications, including diabetes meds or insulin, anticoagulants or antiplatelets, or drugs metabolized by CYP3A4/P-gp

In the phase III liraglutide program (SCALE study) ~4000 participants with obesity were studied for up to three years [16]

Clinically, observational data suggest a 19% lower glaucoma incidence in GLP-1RA-treated diabetic patients than those on other antidiabetic regimens (Figure 1, this review comprehensively analyzes the mechanistic basis of GLP-1RAs in ocular diseases, synthesizes emerging clinical and preclinical evidence, and underscores their potential to redefine therapeutic strategies for vision-threatening disorders through multi-targeted disease modification

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Methods Mice Wild-type C57BL/6J (B6) were purchased from Charles River (stock number JAX 000664)