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This chemogenetic sensor possesses a unique reactivity turn-on mechanism, ensuring that the small molecule is only sensitive to GSH in a desired location
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O 2 - ), hydroxyl radicals (
It achieves this by: Inhibiting Melanin Production: Glutathione suppresses the activity of the enzyme tyrosinase, which is responsible for melanin synthesis
doi:10.1128/AAC.00719-10 89
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