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Ethics declarations Ethics approval All experimental procedures were performed in accordance with international guidelines for the care and use of laboratory animals, including the ARRIVE guidelines, and were consistent with national regulations

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doi:10.1186/s12916-016-0657-8

Secondly, ketone bodies are metabolized in mitochondria, resulting in less NAD + consumption and an increase in the NAD + /NADH ratio in the cytoplasm (144)