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Clinical trials showed average weight loss of about 12% of body weight over 72 weeks

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Numerator links survey responses from 150,000 households on GLP-1 medication adoption and timing to food purchases to provide a representative panel of households in the United States

In studies with rodents, GLP-1 medicines caused thyroid tumors, including thyroid cancer

The implications of centrally produced, neuromodulatory GLP-1 in the context of GLP-1RAs are uncertain, as the degree to which signals from pre-proglucagon neurons/endogenous GLP-1 system and GLP-1RA activity converge on shared downstream targets is unclear 6 and may in fact occur independently 7