Population Pharmacokinetic Modelling Datasets containing plasma concentration and covariate data from each trial were converted to a format compatible with the nonlinear mixed-effects modelling (NONMEM) software (ICON Development Solutions, Ellicott City, MD, USA), version 7.1.2
Patients with obesity, or overweight plus a weight-related condition, on the 2.4 mg maintenance dose lost 15% on average (vs ~2%)
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More consistent energy throughout the day
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