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According to the FDA and KDIGO-ADA 2022 guidelines, liraglutide, semaglutide, and tirzepatide generally do not require dose adjustments in CKD patients
Moreover, these alterations may contribute to increased anxiety, reduced self-control, and a greater propensity for impulsive or dominant behaviours, particularly in individuals with pre-existing traits such as poor impulse regulation or antisocial tendencies (59, 60)
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