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N Engl J Med 841851

doi:10.1016/j.molmet.2021.101181 64

While these effects may be beneficial in selected cardiovascular indications, they raised concerns regarding hypotension and hemodynamic instability when considered for chronic metabolic disease

found downregulation of oxidative stress and neuronal death after injection of the phenolic substance geraniin by the middle cerebral artery occlusion-reperfusion (MCAO/R), and OGD/R models, as well as by neurological scoring assays, CCK8 assessment, TUNEL staining, detection of cells by flow cytometry, and Western blotting assessment ( ex vivo and in vivo Nrf2, HO-1 protein expression in a concentration-dependent manner in the tMCAO model (Chumboatong et al., 2020)

A spokesperson for the Medicines and Healthcare products Regulatory Agency (MHRA) said it is aware of Lemon Bottle but has determined it is not a medical product or medical device