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It is important to note that GLP-1 receptor agonists are prescription-only medicines in the UK, regulated by the Medicines and Healthcare products Regulatory Agency (MHRA), and should only be used under medical supervision as part of a comprehensive weight management programme

Among these agents, semaglutide and liraglutide have consistently shown the strongest cardiovascular benefit, with semaglutide showing additional promise in patients with obesity and HFpEF

Clin Chem Lab Med

Metabolism 64 , 11341145 (2015)

The net effect of the mismatch between increased ATP demand and decreased ATP generation is increased renal oxygen consumption, ultimately rendering the kidney susceptible to renal hypoxia [15]