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Other factors that can hinder A clearance include extracellular proprotein convertase subtilisin/kexin type 9 (PCSK9) impacting LRP1 on ECs and altered expression of -site amyloid precursor protein cleaving enzyme 1 (BACE1) [175, 176]

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After first-line treatments and diagnostics, including diet change, addition of probiotics, and fecal analysis, were performed, a GI panel determined serum cobalamin, folate, and trypsin-like immunoreactivity