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The synergistic interplay among withanolides, sitoindosides, and saponins seemingly propels the adaptogenic attributes of Ashwagandha by modulating the responses of stress hormones, regulating neurotransmitter systems, and augmenting the expression of neurotrophic factors
doi: 10.1128/mbio.02578-22 198 MulemeHMRegueraRMBerardAAzinwiRJiaPOkworIBet al
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Activation in the area postrema (AP) The area postrema is a circumventricular organ , a region of the brain that has no blood-brain barrier , so peptide hormones from the blood have direct access to it
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