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Cuomo notes that while these results are observational, they underscore an urgent need for clinical trials to test whether GLP-1 drugs can improve cancer survival rates, especially for patients with obesity-related cancers

These medications, which include semaglutide (sold as Ozempic and Wegovy) and tirzepatide (sold as Mounjaro and Zepbound), work by mimicking a natural hormone that regulates appetite, slows gastric emptying, and influences how the brain perceives hunger

Serious Side Effects (Less Common but Severe) Pancreatitis (inflammation of the pancreas) Gallbladder problems (gallstones) Kidney injury (due to dehydration from severe vomiting or diarrhea) Thyroid tumors (found in animal studies but unclear risk in humans) Hypoglycemia (low blood sugar) Additional Risks with Compounded Semaglutide Since compounded semaglutide lacks FDA approval and its formulation can vary, it may carry extra risks, including: A dose may be stronger or weaker than expected Affecting blood sugar control and weight loss

They then elegantly translated this finding to study women with two variant Mc1r alleles and confirmed a greater response to -opioids, such as pentazocine, than dark-haired controls