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While consensus does not exist regarding the exact synergistic mechanisms by which dual-agonists work, the addition of GIP agonism is posited to improve the HbA1c control and weight loss offered by GLP-1 agonists alone by enhancing insulin secretion, decreasing energy consumption, and stimulating satiety in the hypothalamus

Each amino acid must be added in precise sequence, the fatty acid must be attached at the correct position, and the final product must be purified to greater than 99% purity (Lau & Dunn, Bioorganic & Medicinal Chemistry 2018)

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