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The only valid comparison is clinical outcome (weight loss, appetite suppression, blood sugar control), not milligram dose

For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]

The broader health impacts of GLP-1s are just beginning to be felt, showing incredible promise in improving metabolic health and even treating addiction

Still, these numbers shouldnt be treated as a head-to-head comparison

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