Although oral semaglutide was projected to increase costs over the long term, these were partially offset by cost savings from avoidance of diabetes-related complications, and ICERs in the base case analyses and in the majority of wide-ranging sensitivity analyses were estimated to be under the commonly used willingness-to-pay threshold of EUR 30,000 per QALY gained in Portugal
GLP-1 slows down digestion, changing the way the body processes food and produces energy
Yet, we found that combination therapy was already occurring in real-world practice, with most patients receiving GLP-1 therapy before surgery. This suggests that clinicians are beginning to individualize treatment pathways even in the absence of formal guidance, highlighting how rapidly the field is evolving. This shift shows that obesity care is undergoing a rapid transformation
Funding This research was funded with both national and international resources coming from governmental institutions such as CONACyT (Consejo Nacional de Ciencia y Tecnologa) and private resources from Palsgaard Industri de Mxico S
Additionally, the condition promotes water retention and reduces physical activity tolerance due to fatigue and muscle weakness
