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Loading phase (deficiency): 1000 mcg IM or subQ daily or every other day for 1 to 2 weeks Maintenance: 1000 mcg monthly is a standard maintenance dose for conditions like pernicious anemia Wellness protocols: may use lower doses weekly, though this is less established clinically In ml: cyanocobalamin is typically supplied at 1000 mcg/ml, so a 1000 mcg dose equals 1 ml

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doi: 10.1016/J.CPCARDIOL.2024.102721 43 AkilLAnwar AhmadH

Transient activation of AMPK can inhibit protein synthesis through phosphorylation of elongation factor-2 kinase 37 and suppression of the mTOR pathway 38 , thus enhancing the restoration of cellular energy homeostasis and alleviating the burden of the unfolded nascent polypeptides 31

Multi-targeting andrographolide, a novel NF-B inhibitor, as a potential therapeutic agent for stroke