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Candidates must have high potency at both receptors, but it is unclear whether the limited experimental data available can be used to train models that accurately predict the activity at both receptors of new peptide variants
It is not a GLP-1 agonist drug, nor is it intended to replace GLP-1 agonist drugs
GLP-1 RAs reduce cardiovascular risks but may cause nausea and GI issues
Gpx has been shown to degrade lipid hydroperoxides to their respective alcohols and free hydrogen peroxide to water [82, 83], hence reducing oxidative damage [81]
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