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Theres also greater than 5-fold variability in response to the same energy deficit or surplus between individuals, which is mostly attributed to genetics
Semaglutide also improves metabolic health by regulating blood sugar levels
Begin with 250mcg daily for the first week to assess tolerance
Hydration is everything This is the single most important protective measure
Different GLP-1 medications may have varying effects on gastric emptying (short-acting GLP-1s typically have greater effects than long-acting ones), and switching formulations may provide better tolerability whilst maintaining therapeutic benefits
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