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The question is "what is the probability of harm over 30+ years of periodic use, given that no one has studied it for even 5 years in this population?" That question has no answer

Currently in Phase 3 trials (TRIUMPH), it is not yet FDA-approved, with anticipated availability in late 2026 to 2027 Key concern with retatrutide is that while weight loss is impressive, it comes with a higher burden of GI side effects (nausea, vomiting, diarrhea) due to strong multi-receptor stimulation

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Why Do We Offer Compounded Semaglutide as an Option

Semaglutide effects on the progression to type 2 diabetes among individuals with prediabetes. Nature Medicine , 2024