SGLT2is remained cost-effective at a threshold of AU$28,000 per QALY gained under all scenarios in the total and secondary prevention populations, except when the price of SGLT2is was set at AU$7000 (US price), when the timeframe was reduced to 20202030, and when the efficacy was reduced by 5% per year
Generics typically occupy the lowest tier, then preferred brands, then nonpreferred brands, then specialty drugs at the highest tier
However, this regulation appears to be complex, likely as a result of the contribution of multiple sites throughout the CNS that target distinct elements in peripheral tissues that play a role in the control of glucose homeostasis
The 4-week titration interval is not arbitrary: retatrutide takes approximately 4 to 5 weeks to reach steady-state plasma concentration at each dose level, given its half-life of approximately 6 days
GLP-1 Agonists and Thyroid Cancer Risk The most comprehensive analysis of thyroid cancer risk with GLP-1 agonists was published in The Lancet Diabetes & Endocrinology