surpass 6 tirzepatide Flow of Participants in the SURPASS-6 Trial See Table 3 for the details A Study of Tirzepatide (LY3298176)

Within the GLP-1 RA + CKD group, eGFR reduced from 50.1 ml/min per 1.73 m 2 to 44.8 ml/min per 1.73 m 2 at 5 years

The basic reason GLP-1R agonism works for weight loss is that GLP-1 regulates appetite

The New England Comparative Effectiveness Public Advisory Council (CEPAC), a nationally recognized independent appraisal committee for ICER, found that adding tirzepatide to background therapy is superior to background therapy alone in a vote of 13 yes to 0 no

doi: 10.1053/j.anndiagpath.2004.04.003 18 MoreauAGalmicheLBelhousKFranchiGCouloignerVNevouxJet al

Insulin and IGF-1 signaling GLP-1 medications improve insulin sensitivity, which is one of their major metabolic benefits