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Physiol., vol

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Results showed 65% of patients achieved clinical remission compared to 32% receiving standard therapy alone

Accordingly, despite losing 25% of their body mass, GLP-1MK-801-treated mice maintained an energy expenditure that was similar to that of vehicle-treated control mice and was therefore also significantly higher than the gradually decreasing energy expenditure observed in mice that were calorie-restricted to match the weight loss trajectory of GLP-1MK-801-treated mice

These limitations have contributed to the lack of conclusive clinical efficacy observed to date (Kurkinen, 2023)