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Flavonoids, such as quercetin and kaempferol, reduce this proliferation by modulating miRNAs like miR-21 and miR-145, thereby inhibiting VSMC proliferation and preventing arterial stenosis ( Reduction of Vascular Inflammation: Flavonoids decrease vascular inflammation by suppressing the expression of pro-inflammatory miRNAs, such as miR-155, which reduces immune cell infiltration into atherosclerotic plaques ( 5 Preclinical and clinical evidence The modulation of microRNAs (miRNAs) by flavonoids within the context of cardiovascular disease (CVD) represents an emerging area of research, with growing evidence suggesting beneficial effects of flavonoids on cardiovascular health via miRNA regulation

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells