Potentially severe side effects of Trulicity: Hypoglycemia Gastroparesis (stomach paralysis) Ileus (intestinal blockage) Gallbladder disease Kidney damage Pancreatitis Thyroid tumors (Trulicity carries a boxed warning of thyroid tumors after studies showed an increased risk in animals, but had unclear implications for humans) Allergic reactions Signs and symptoms of serious side effects may include severe abdominal pain, persistent nausea, vomiting, fever, dark urine, or signs of an allergic reaction
The studies range from phase I to IV, with sample sizes varying from 30 to 890 participants, predominantly involving adult populations
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Mannervik B, Castro VM, Danielson UH, Tahir MK, Hansson J, Ringborg U
The research (which analyzed data from millions of patients) found that individuals taking these medications faced dramatically elevated risks for multiple severe gastrointestinal conditions that often occur in sequence beginning with pancreatitis and potentially progressing to gastroparesis