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Enteroendocrine cells (EECs), the microbiota, and metabolites produced by the microbiota constitute a complex signaling system [13] that involves the enteric plexus, CNS afferents and efferents, and the modulation of numerous brain nuclei like the nucleus tractus solitarius, hypothalamus, thalamus, and many others directly involved in the control of glucose and energy homeostasis [14]
The practical significance of these interactions is debated and depends heavily on formulation, concentration, and pH
Patients should avoid self-sourcing and should speak with a licensed provider about safety, legal status, and medically supervised options
The fiber and prebiotics market is entering a period of reassessment rather than expansion
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