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The SURMOUNT-1 trial (tirzepatide, published in NEJM 2022) demonstrated that participants with obesity or overweight without diabetes who received tirzepatide experienced weight reductions of 16.0% (5mg), 21.4% (10mg), and 22.5% (15mg) over 72 weeks
Its important for these patients to talk to their doctor about how semaglutide could interact with their current medications
This is a meaningful biological effect, but it operates at a different scale and duration than pharmaceutical GLP-1 agonists
Reddys Eris Lifesciences Emcure Pharmaceuticals Glenmark Pharmaceuticals Lupin MSN Natco Pharma Novo Nordisk Sun Pharma Torrent Pharmaceuticals USV Zydus In addition, more than 20 companies have sourced semaglutide API in the past 12 months, suggesting a second wave of entrants that are either delayed or taking a wait-and-see approach amid downward pricing pressure (Figure 1)
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